Scientists transplanted hBMSCs in mice.
Chinese researchers have created humanized mice to study the effects of hepatitis b, informs Rus.Media.
Humantay or humanized mouse – an animal which contained a functioning human immune cells.
To create an ideal animal model of infection with hepatitis b virus is difficult because the virus has an extremely narrow range of substrates and affects almost only humans.
Previous studies show that stem cells of human bone marrow (hBMSCs) in laboratory conditions have the potential to split into hepatocyte-like cells and maintain the basic life functions of liver cells outside a living organism after transplantation into the liver of the mouse. Hepatocytes make up 70 to 85 percent of the mass of the liver.
Scientists transplanted hBMSCs in mice. Functional human hepatocytes and multiple immune cells showed a high ability to differentiate.
After Contracting hepatitis b in the body humanized mice showed particular immune and inflammatory responses, and symptoms of progressive liver cirrhosis and chronic hepatitis.
According to the opinion of scientists, infection with hepatitis causes a new model of humanized mice with liver cirrhosis. Thus, the results of the study provide material for a better understanding of the immune pathophysiology of the virus and the testing of antiviral therapies in the future.