Combination therapy based on chloroquine not recommended by a panel of experts

La bithérapie à base de chloroquine déconseillée par un panel d’experts

Washington | A group of american experts under the aegis of the national Institutes of health formally recommended that physicians treat their patients COVID-19 with the dual treatment hydroxychloroquine and azithromycin, because of the risks to the heart.

“With the exception of the context of clinical trials, the panel (…) recommends that you do not use the following drugs for the treatment of the COVID-19: the combination of hydroxychloroquine and azithromycin, because of the toxicities potential “, warns the group in the clinical guidelines published on Tuesday, as discouraging also the anti-HIV drug lopinavir/ritonavir.

The panel is made up of dozens of representatives of the national Institutes of health, professional organizations of doctors, universities, hospitals and federal agencies. It provides guidance for the management of patients with the new coronavirus on the basis of the studies carried out to date.

“Currently, no medication has demonstrated that it is safe and effective for treating COVID-19 “, written in bold the group of experts.

About taking only hydroxychloroquine, without the antibiotic azithromycin, as well as the antiviral remdesivir, the panel explained that there is not yet rigorous studies to enable a decision in one direction or the other.

“There is not enough clinical data to recommend for or against the chloroquine or hydroxychloroquine,” write the experts of the panel.

“If chloroquine or hydroxychloroquine are used, clinicians need to monitor the occurrence of adverse effects in the patient, including the QTc interval “, warn they. This means that these molecules can, in some patients, can cause heart rhythm problems, a known effect because the drug is used for a long time against malaria.

Hydroxychloroquine is given in dual therapy with the antibiotic azithromycin in many hospitals around the world, and the cocktail is particularly promoted by the French physician Didier Raoult. This scientist is very critical of the experts arguing that there must be clinical trials more rigorous to know if it really is this cocktail of molecules that has helped many of his patients heal from the COVID-19. Such trials are underway.

The us president, Donald Trump has initially touted also this combination regimen as a ” gift from heaven “, but recently, in the face of the controversy, and after that doctors have reported worrying results, it is no longer referred to the chloroquine.

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