Chronic enteritis and chronic colitis – chronic inflammatory bowel disease, leading to morphological changes in the mucosa and impaired motor, secretory, absorptive, and other functions of the intestine.
How to remove inflammation of the intestines?
Etiotropic therapy of chronic enteritis and colitis involves the normalization and quality of supply, eliminate the effect on the intestine of toxic and other damaging factors (deworming) treatment of comorbidity.
Pathogenetic therapy in inflammatory bowel disease includes a diet number 4 or number 2 by Pevsner, containing sufficient amounts of animal protein, easily digestible fats, and vitamins. Excluded from the diet spices, meats, milk, foods that cause flatulence.
For the normalization of motor activity during inflammation of the intestine is used adsorbents and binding agents (Polifepan, use adsorbents, Smectite, bismuth preparations),antidiarrheal agents (Imodium, fruit cherry, blueberries, grass Hypericum, stems gray alder, and black oak bark, pomegranate peel).
To reduce inflammation, modern medicine also provides for the appointment of antihistamines (Suprastin, Tavegil, Diphenhydramine), corticosteroids (Prednisone), Sulfasalazine.
For constipation on the background of inflammation of the intestine appointed laxatives (Bisacodyl, drugs rhubarb, Kapil, Lactulose, dietary bran) and antispasmodics (no-Spa, Papaverine).
To eliminate dysbiotic disorders (dysbiosis) use eubiotics and drugs that suppress pathological microflora (Mexaform, derivatives of Hydroxyquinoline), bacterial preparations (Bifikol, Baktisubtil, Linex), multienzyme preparations (Pancreatin, panzinorm, Festal).
How to treat intestinal inflammation in ulcerative colitis?
Ulcerative colitis (UC) is a disease that is characterized by inflammation of the intestines erosive-ulcerative lesions and involvement of other organs (liver, joints, skin). The treatment of intestinal inflammation in this disease are aimed at achieving remission of the disease and prevention of complications. In mild ulcerative colitis to relieve inflammation of the intestines as an outpatient, other forms of the disease require treatment in hospital. Patients assigned to the diet with a high protein content (diet No. 46 by Pevsner)
Methods of treatment of intestinal inflammation in ulcerative colitis
Drug therapy of inflammatory bowel disease is carried out by 5-aminosalicylic acid (Mesalazine, salofalk worth us), glucocorticoids. Effective for inflammation of the intestine the intake of these drugs both internally and topically (rectal) in suspension. In complex therapy of ulcerative colitis to relieve inflammation of the intestines, used drugs interferon (IFN), antibiotic therapy with Metronidazole or broad spectrum antibiotics, eubiotikami. The patient shows the introduction of the protein solutions (10 or 20 % solutions albumin, solutions of amino acids) and vitamins A, E, C, PP.
Physical methods of treatment of patients with colitis is aimed at:
1. gain (colonostomy methods)
2. broken or loose motor function of the intestine (chronomodulated methods),
3. decrease (muscle relaxant therapies for intestinal inflammation)
4. or increase (myostimulating methods) of its tonus of smooth muscles
5. and restoration of damaged intestinal micro flora (biotic treatments of inflammation of the intestine).
The causes of intestinal inflammation
Inflammatory bowel disease, chronic enteritis and chronic colitis – independent of the disease, often combined with each other and similar in etiology and pathogenesis. They are the most frequent pathologies of the intestine and may accompany other diseases of the digestive system.
The causes of intestinal inflammation in chronic enteritis
Cause inflammation of the intestine against chronic enteritis can be chronic intoxication, food Allergy, parasitic infestation, congenital enzima-TII small intestine, re-foodborne diseases.
The pathogenesis of intestinal inflammation composed of several main parts, which closes the vicious circle. The first is a chronic damaging effect of etiological factors on the wall of the small intestine. The result is a violation of the protective barriers of the mucous membrane (glycocalyx, system of lysozyme, local, cellular and humoral immunity).
The next link in the pathogenesis of intestinal inflammation – the development of hypersensitivity to bacterial antigens, the products of hydrolysis of food proteins, the proteins of the damaged intestinal wall and the formation of tissue inflammation. Disruption of the normal mechanisms of digestion and absorption contributes to the “settling” of the small intestine with improper microflora. The latter circumstance leads to further damage of the mucosa are formed toxic and antigenic substances.
The causes of intestinal inflammation in ulcerative colitis
The etiology of ulcerative colitis has not been established definitively. Were put forward different assumptions for the development of the disease. The most thoroughly discussed infectious theory of the development of ulcerative colitis – cytomegalovirus, certain strains of E. coli and other bacteria. From environmental factors, which can also be considered as the conditions under which it is easier the inflammation of the intestine against ulcerative colitis, can also be specified diet: excessive consumption of easily digestible carbohydrates with an insufficient amount of fiber, as well as neuro-psychiatric effects. Of great importance in the occurrence of ulcerative colitis has a genetic predisposition.
In the development of intestinal inflammation an undoubted value has a change in immune status, especially of the intestinal immune system, activation of lipid peroxidation against the background of progressive apoptosis in the mucosa. When ulcerative colitis subpopulation of T-lymphocytes in the gut are particularly active. In addition, under the influence of etiological factors in the mucosa of the marked enhancement of apoptosis that contributes to the activation of inflammatory reactions. With ulcerative colitis strengthens the processes of lipid peroxidation on the background of exhaustion of the function of the antioxidant system, leading to pathogenic effects of free radicals and the development of hyperergic inflammation of the intestine.
Causes inflammation of the intestines chronic ulcerative colitis
Chronic ulcerative colitis is caused by pathogens of intestinal infections (Salmonella, pathogenic intestinal microflora, etc.), mushrooms, intestinal amoebas, Giardia, and helminths, which create conditions for the maintenance of inflammation in the colon. Have the nutritional value of the factor, and concomitant diseases of digestive organs, chronic intoxication, domestic and industrial toxins, radiation exposure, inappropriate medications (antibiotics, laxatives), long koprostaz (narrowing of the lumen of the intestine adhesions, malformations).
The primary mechanism for development of intestinal inflammation in chronic ulcerative colitis in most cases, is a direct irritant and damaging effect of various mechanical and toxic factors on the wall of the colon. Infectious and protozoal colitis become chronic while reducing the immunological reactivity of the organism, as well as sensitization to the damaged epithelium of the intestinal wall and to antigens of infectious origin. Contribute to re-infection and persistence of the pathogen in the intestinal wall. Occur when inflammation of the cause kishechnorastvorimye:
1. violation of motor function of the intestine,
3. intestinal exudation
4. and the disorder of the processes of absorption in the intestine.