This discovery brings us closer to the day when we can regenerate amputated limbs in humans.
Researchers from the University of Texas have identified two proteins, which may partially stimulate the growth of amputated finger in mice.
Although scientists have achieved growth of bone in previous studies, this paper demonstrates signs of growth of the joints is a whole other level, which previously was impossible to achieve, informs Rus.Media.
Pre-regenerative bone in mice with the use of BMP2 protein, the researchers in the new study, added another one – BMP9. When using this combination more than 60 percent of the bones of the foot formed a layer of cartilage within three days, while no proteins amputated fingers would heal as usual. This cartilage is considered a key part of the joints and shows some progress in the regeneration of limbs. Even in animals, many of which can grow back lost limbs, rarely growing joints and bones.
“The results of our study indicate that treatment with growth factors can be used to create regeneration informed aregenerous amputation wounds,” the researchers explain in their paper, which was published in the journal Nature Communications.
The test results showed that regeneration was most efficient when applied immediately BMP2 and BMP9 was added a week later: this has led to the growth of more full articular structures – even some connections with the bone. Of course, we are still far from full recovery of the limbs in mice, not to mention the people, but this work is a resolute step in this direction. The human skeleton is like the skeleton of a mouse, and because scientists do not lose hope to transfer these results to humans.
According to one of the authors, employees of the University of Texas Muneoka Ken (Ken Muneoka), new research is transformational and the results show that mammalian cells can regenerate body parts with the right approach. They are capable of, just don’t do it, and, according to the scientist, the goal is to figure out what is holding them back.
Scientists will need more than one study, to understand how to “turn on” these cells, but the team full of hope. In the end, this work can help in the treatment of degenerative joint diseases such as osteoarthritis, and in their research, the experts draw inspiration from the animal world – read more studying, as, for example, Triton is able to regenerate limbs. As suggested Muneoka, this is due to the activation of desired cells. If, as a result, scientists will be able to develop methods of restoring lost limbs, proteins BMP2 and BMP9 may well have to do with it.